The Los Angeles Chargers are on the verge of making a significant splash in the 2025 NFL season, as they are reportedly eyeing a surprising trade with the San Francisco 49ers. According to sources from Sporting News, the Chargers’ target is none other than promising young running back Isaac Guerendo, a talent selected by the 49ers in the fourth round of the 2024 NFL Draft. If successful, this trade could provide a major boost to the Chargers’ offense, particularly as they aim to maximize the effectiveness of star quarterback Justin Herbert.

Guerendo – The Perfect Fit for Jim Harbaugh’s Philosophy
Isaac Guerendo, standing at 6 feet and weighing 221 pounds, has shown glimpses of his potential in limited appearances during the 2024 season. His impressive speed (4.33 seconds in the 40-yard dash) combined with powerful running and agility makes him an ideal candidate for the power-oriented offensive scheme of head coach Jim Harbaugh. Harbaugh, who previously led the Michigan Wolverines to an NCAA national championship, is renowned for building balanced offenses where the role of running backs is heavily emphasized.
Currently, the Chargers rely on J.K. Dobbins and Gus Edwards as their primary running backs, but both have concerning injury histories. Adding a talent like Guerendo would not only provide depth to the running back position but also offer a long-term option for the RB3 role, reducing pressure on the starters and adding versatility to the team’s offensive plays.
Challenges from the 49ers
Convincing the 49ers to part with Guerendo, however, will not be an easy task. Under head coach Kyle Shanahan, the 49ers have built one of the NFL’s most formidable offenses, with Christian McCaffrey as the centerpiece at running back. While Guerendo has yet to see significant playing time, he is considered part of the team’s long-term plans, especially as McCaffrey, now 29, has shown signs of wear and tear in recent seasons. Additionally, the 49ers have Jordan Mason, another developing running back, which may give them confidence to retain Guerendo as a high-quality backup.
For this trade to materialize, the Chargers would need to present an enticing offer, potentially including draft picks or a player of comparable value. With ample financial resources and draft capital, the Chargers are well-positioned to meet the 49ers’ demands, but it will require bold decision-making from the team’s front office.
Impact of the Trade
If the Chargers manage to bring Guerendo to SoFi Stadium, it would be a bold statement of their ambitions for the 2025 season. A bolstered offense featuring Guerendo, paired with Justin Herbert’s leadership and Jim Harbaugh’s strategic vision, could position the Chargers as a formidable force in the AFC West, where they face stiff competition from teams like the Kansas City Chiefs.
Moreover, this trade would underscore Harbaugh’s fearless approach to roster-building, as he is known for making unexpected moves to shape the team according to his vision. In an NFL landscape that increasingly values versatility and roster depth, acquiring a dynamic running back like Guerendo could be the key to propelling the Chargers deeper into the playoffs.
Conclusion
The potential trade between the Chargers and 49ers is generating buzz among NFL fans, as both teams pursue their respective goals and strategies. For the Chargers, this is an opportunity to strengthen their offense and signal to rivals that they are ready to compete at the highest level. However, with the 49ers’ reluctance to let go of their young talent, the Chargers will need to act swiftly and decisively to make this shocking trade a reality. Can Jim Harbaugh and his team pull off a game-changing move for the 2025 season? The answer will likely unfold in the coming weeks.