The Buffalo Bills are favored in every 2025 game, sparking major Super Bowl hopes and marking a historic scheduling advantage. (Credit: Getty Images)
The Buffalo Bills are no strangers to dominating the regular season. Under the dynamic pairing of quarterback Josh Allen and head coach Sean McDermott, the team has built a reputation for consistent excellence. With five straight playoff appearances since 2019 and double-digit wins in each of those seasons, Buffalo has proven time and again they belong among the NFL’s elite. Yet, the postseason narrative hasn’t been as kind — especially with
Patrick Mahomes and the Kansas City Chiefs consistently standing in their way.
Every 2025 game favors the Bills—analysts already calling it the softest schedule of the season
Last year’s heartbreaker — a 32-29 loss in the AFC Championship Game — still stings. But Buffalo isn’t dwelling on the past. The 2025 season offers a clean slate, and with a loaded roster and a favorable schedule, the Bills have every reason to believe this could be their year. Josh Allen, now one of the league’s premier quarterbacks, will be hungrier than ever to deliver the franchise its first Lombardi Trophy after coming up short once again in 2024.
The optimism surrounding Buffalo is not just fan-driven hype — oddsmakers are equally bullish. Following the release of the 2025 NFL schedule, the Bills are favored in all 17 of their regular-season games. That hasn’t happened since 1960, except once before in 2022. This kind of widespread confidence from Vegas speaks volumes about how the team is viewed on paper.Their schedule is about as friendly as it gets for a contender. Buffalo has one of the NFL’s easiest slates in terms of opponent strength and travel demands. In fact, they’ll log the second-fewest travel miles this season — a subtle but significant edge as the grind of the season wears on. Add in the fact that none of their AFC East rivals have projected win totals over 8.5, and Buffalo looks poised to clinch their sixth consecutive division title.As Gary Davenport of Bleacher Report puts it: “They open with a tough one against the Baltimore Ravens. But if the Bills can prevail at home in that game, there’s a real chance they could hit their bye week undefeated. After that opener, the Bills get more cupcakes than Baked by Melissa.”If things fall into place early, Buffalo could be 6-0 heading into their bye, with only the Ravens posing a significant threat during that stretch. Matchups with the Panthers and a struggling NFC South should further boost their win total. The true tests will come in the form of home games against the Bengals, Chiefs, Eagles, and Ravens — but having all of those clashes in Orchard Park might just tilt the scale in their favor.At +750, the Bills are tied with Kansas City for the third-best
Super Bowl odds
. They trail only the Chiefs and Ravens in the AFC race, with odds at +375 to win the conference. But unlike previous seasons, this time feels different. Buffalo isn’t just a contender on paper — they have the tools, the talent, and the motivation to finish the job.Josh Allen knows what’s at stake. The window is open, and after multiple near-misses, the star quarterback will be out to turn promise into a championship. With a favorable schedule, home-field advantages, and a chip on their shoulders, the Bills are marching into 2025 ready to silence the doubters — once and for all